Oncogenes MYC, MAX, and MNT upregulate branched chain amino acid metabolism in peripheral T cell lymphoma
Location
E4118
Document Type
Poster
Start Date
30-11-2023 3:50 PM
End Date
30-11-2023 4:30 PM
Description
Abstract
Peripheral T cell lymphoma (PTCL) is an aggressive non-Hodgkin lymphoma arising in T lymphocytes. Overexpression of the oncogenes MYC, MAX, and MNT is implicated in non-Hodgkin lymphomas where these genes control growth and proliferation by regulating the expression of metabolic genes. The mitochondrial branched-chain aminotransferase (BCAT2) and ketoacid dehydrogenase (BCKDHA, and DBT) genes encode for enzymes that breakdown branched-chain amino acids (BCAAs). BCAAs are a source of energy and metabolites for lymphoma cells. We aimed to investigate whether the expression of MYC, MAX and MNT correlate with that of BCAT2, BCKDHA, and DBT and to understand whether overexpression of BCAT2, BCKDHA and DBT in PTCL patients correlates with lower cancer survival.
The genomics analysis and visualization platform (R2) was used to access information about the overall survival and gene expression of 193 specimens from newly diagnosed PTCL patients. Kaplan Meier survival curves were downloaded from the platform along with the 2log expression values of each gene of interest. Pearson’s correlation coefficient (R) was used to measure the strength and direction of the relationship between the oncogenes and the metabolic genes.
Results indicated a positive and statistically significant correlation between BCAT2 and MYC, BCKDHA and MYC/MAX, and DBT and MAX/MNT. Overexpression of BCAT2, BCKDHA, and DBT correlated with significantly lower PTCL survival. The findings suggested that the oncogenes upregulate the BCAA metabolic genes in PTCL. While the molecular mechanism of these correlations needs to be addressed experimentally, the findings may serve as a basis for future pharmacotherapy for PTCL patients.
Recommended Citation
Khan, Taha and Ananieva, Elitsa, "Oncogenes MYC, MAX, and MNT upregulate branched chain amino acid metabolism in peripheral T cell lymphoma" (2023). DMU Research Symposium. 19.
https://digitalcommons.dmu.edu/researchsymposium/2023rs/2023abstracts/19
Oncogenes MYC, MAX, and MNT upregulate branched chain amino acid metabolism in peripheral T cell lymphoma
E4118
Abstract
Peripheral T cell lymphoma (PTCL) is an aggressive non-Hodgkin lymphoma arising in T lymphocytes. Overexpression of the oncogenes MYC, MAX, and MNT is implicated in non-Hodgkin lymphomas where these genes control growth and proliferation by regulating the expression of metabolic genes. The mitochondrial branched-chain aminotransferase (BCAT2) and ketoacid dehydrogenase (BCKDHA, and DBT) genes encode for enzymes that breakdown branched-chain amino acids (BCAAs). BCAAs are a source of energy and metabolites for lymphoma cells. We aimed to investigate whether the expression of MYC, MAX and MNT correlate with that of BCAT2, BCKDHA, and DBT and to understand whether overexpression of BCAT2, BCKDHA and DBT in PTCL patients correlates with lower cancer survival.
The genomics analysis and visualization platform (R2) was used to access information about the overall survival and gene expression of 193 specimens from newly diagnosed PTCL patients. Kaplan Meier survival curves were downloaded from the platform along with the 2log expression values of each gene of interest. Pearson’s correlation coefficient (R) was used to measure the strength and direction of the relationship between the oncogenes and the metabolic genes.
Results indicated a positive and statistically significant correlation between BCAT2 and MYC, BCKDHA and MYC/MAX, and DBT and MAX/MNT. Overexpression of BCAT2, BCKDHA, and DBT correlated with significantly lower PTCL survival. The findings suggested that the oncogenes upregulate the BCAA metabolic genes in PTCL. While the molecular mechanism of these correlations needs to be addressed experimentally, the findings may serve as a basis for future pharmacotherapy for PTCL patients.
