Therapeutic potential of G1 in treatment of hypertension in an experimental model of sleep apnea
Description
Sleep apnea (SA), a condition characterized by recurrent cessation of breathing during sleep is recognized as an independent risk factor for development of hypertension (HTN). Epidemiological studies show HTN risk is lower in pre-menopausal women with SA relative to similarly aged men with SA, however the risk for women increases after menopause. Previous work done in our lab shows that estrogen loss in female rats via ovariectomy (OVX) results in increases in blood pressure in rats exposed to chronic intermittent hypoxia (CIH, an experimental model of SA). In the current study, we hypothesized that activation of a specific estrogen receptor (GPER, g-protein coupled estrogen receptor) with a selective agonist (G1) would attenuate previously observed increases in arterial pressure in OVX females conditioned with CIH. To address this hypothesis two groups of female rats were conditioned with CIH or a control condition (21% oxygen, AIR) for 14 days while receiving treatment with G1 via osmotic mini pumps. Arterial pressure was measured non-invasively using tail cuff plethysmography and invasively using an indwelling arterial pressure catheter. Analysis is still ongoing, but If our hypothesis is correct, we expect that arterial pressure will be similar between groups exposed to AIR and CIH due to a salutary effect of treatment with G1.
Citation Information
Ordaz, Daniel; Lombardi Labegaline, Julia; Watson, Jackson; Lin, Emma; Kleine, Ryan; Kayser, Anna; Clayton, Sarah C.; and Marcus, Noah J., "Therapeutic potential of G1 in treatment of hypertension in an experimental model of sleep apnea" (2026). Office of Research DMU Research Symposium. 70.
https://digitalcommons.dmu.edu/researchsymposium/2025rs/2025abstracts/70
Therapeutic potential of G1 in treatment of hypertension in an experimental model of sleep apnea
Sleep apnea (SA), a condition characterized by recurrent cessation of breathing during sleep is recognized as an independent risk factor for development of hypertension (HTN). Epidemiological studies show HTN risk is lower in pre-menopausal women with SA relative to similarly aged men with SA, however the risk for women increases after menopause. Previous work done in our lab shows that estrogen loss in female rats via ovariectomy (OVX) results in increases in blood pressure in rats exposed to chronic intermittent hypoxia (CIH, an experimental model of SA). In the current study, we hypothesized that activation of a specific estrogen receptor (GPER, g-protein coupled estrogen receptor) with a selective agonist (G1) would attenuate previously observed increases in arterial pressure in OVX females conditioned with CIH. To address this hypothesis two groups of female rats were conditioned with CIH or a control condition (21% oxygen, AIR) for 14 days while receiving treatment with G1 via osmotic mini pumps. Arterial pressure was measured non-invasively using tail cuff plethysmography and invasively using an indwelling arterial pressure catheter. Analysis is still ongoing, but If our hypothesis is correct, we expect that arterial pressure will be similar between groups exposed to AIR and CIH due to a salutary effect of treatment with G1.
