Screening asymptomatic individuals for Factor V Leiden

Work Type

Poster

Abstract

Research topic: Factor V Leiden (FVL)

Most common inherited thrombophilia (3-7% prevalence in U.S. and Europe)

Learning objectives

  • Discuss the prevalence and pathogenesis of FVL
  • Identify lifetime risk of VTE in heterozygotes and homozygotes
  • Summarize recent recommendations on the clinical utility of screening asymptomatic individuals
  • Analyze recent data on the role of thrombophilia screening in primary thromboprophylaxis
  • Explain why over-screening can be harmful to patients and how targeted screening could be improved

Research question

Should providers be screening asymptomatic individuals for FVL after a family member is diagnosed and/or has a VTE event?

Personal significance

Diagnosed at age 16 with heterozygous FVL after maternal aunt had a PE

Publication Date

5-16-2026

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